Inter-vender and test-retest reliabilities of resting-state functional magnetic resonance imaging: Implications for multi-center imaging studies |
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| Institution: | 1. Department of Radiology, Konkuk University School of Medicine, Republic of Korea;2. Department of Global Biomedical Engineering, IBS Center for Neuroscience Imaging Research, Sungkyunkwan University, Republic of Korea;3. Department of Radiology, Kyunghee University, Republic of Korea;1. Department 5 of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK;2. Natbrainlab, Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK;3. Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, UK;4. Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium;5. Janssen Research and Development LLC, Titusville, NJ, US;6. UCB Biopharma SPRL, Chemin du Foriest B-1420 Braine-l''Alleud, Belgium;7. Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium;1. Department of Psychological and Brain Sciences, University of Delaware, Newark, DE 19716, USA;2. Department of Mathematical Sciences, University of Delaware, Newark, DE 19716, USA;3. Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA |
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| Abstract: | This prospective multi-center study aimed to evaluate the inter-vendor and test-retest reliabilities of resting-state functional magnetic resonance imaging (RS-fMRI) by assessing the temporal signal-to-noise ratio (tSNR) and functional connectivity. Study included 10 healthy subjects and each subject was scanned using three 3 T MR scanners (GE Signa HDxt, Siemens Skyra, and Philips Achieva) in two sessions. The tSNR was calculated from the time course data. Inter-vendor and test-retest reliabilities were assessed with intra-class correlation coefficients (ICCs) derived from variant component analysis. Independent component analysis was performed to identify the connectivity of the default-mode network (DMN). In result, the tSNR for the DMN was not significantly different among the GE, Philips, and Siemens scanners (P = 0.638). In terms of vendor differences, the inter-vendor reliability was good (ICC = 0.774). Regarding the test-retest reliability, the GE scanner showed excellent correlation (ICC = 0.961), while the Philips (ICC = 0.671) and Siemens (ICC = 0.726) scanners showed relatively good correlation. The DMN pattern of the subjects between the two sessions for each scanner and between three scanners showed the identical patterns of functional connectivity. The inter-vendor and test-retest reliabilities of RS-fMRI using different 3 T MR scanners are good. Thus, we suggest that RS-fMRI could be used in multicenter imaging studies as a reliable imaging marker. |
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