To what extent can an uncertainty calculation be general? |
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Authors: | I Kuselman |
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Institution: | (1) The National Physical Laboratory of Israel, Givat Ram, Jerusalem 91904, Israel Tel.: +972-2-6536534; Fax: +972-2-6520797; e-mail: kuselman@netvision.net.il, IL |
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Abstract: | It is argued that results of uncertainty calculations in chemical analysis should be taken into consideration with some caution
owing to their limited generality. The issue of the uncertainty in uncertainty estimation is discussed in two aspects. The
first is due to the differences between procedure-oriented and result-oriented uncertainty assessments, and the second is
due to the differences between the theoretical calculation of uncertainty and its quantication using the validation (experimental)
data. It is shown that the uncertainty calculation for instrumental analytical methods using a regression calibration curve
is result-oriented and meaningful only until the next calibration. A scheme for evaluation of the uncertainty in uncertainty
calculation by statistical analysis of experimental data is given and illustrated with examples from the author's practice.
Some recommendations for the design of corresponding experiments are formulated. |
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Keywords: | Analysis uncertainty Uncertainty in uncertainty Statistical estimations Analytical method validation Design of experiment |
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