| β-C（sp3）-H chlorination of amide derivatives via photoinduced copper charge transfer catalysis |
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| 作者姓名： | Yuhang He Chao Tian Guanghui An Guangming Li |
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| 作者单位： | Key Laboratory of Functional Inorganic Material Chemistry (MOE), School of Chemistry and Materials Science, Heilongjiang University |
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| 基金项目： | support from the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province No UNPYSCT-2017124 |
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| 摘 要： | An atom economic β-C（sp3）-H chlorination of amide derivatives has been developed. This mild protocol employs CuCl2 instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives. Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer（LMCT）/1,4-hydrogen atom transfer（HAT） cascade.
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