Determination of catalytic oxidation products of phenol by RP-HPLC |
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Authors: | Jun-Qin Qiao Na Yuan Chang-Jin Tang Jing Yang Jian Zhou Hong-Zhen Lian Lin Dong |
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Institution: | 1. Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing, 210093, China 2. State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, 22 Hankou Road, Nanjing, 210093, China 4. School of Chemistry & Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China 3. Key Laboratory of Mesoscopic Chemistry, Ministry of Education of China, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
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Abstract: | A reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet detection was established for the determination of phenol, catechol, hydroquinone, and p-benzoquinone in the reaction solution of catalytic oxidation of phenol using hydrogen peroxide as the oxidant and copper-doped FeSBA-15 zeolite as the catalyst. Separation was accomplished on a reversed-phase C18 column, and the elution condition was optimized by changing the composition of the mobile phase. A good resolution of all of the relative components in the reaction solution was achieved when the mobile phase was methanol–water–1% acetic acid aqueous solution = 10:50:40 (v/v/v). The concentrations of phenol, catechol, hydroquinone, and p-benzoquinone were determined in 11 different reaction solutions by the external standard method. The proposed HPLC method was simple, accurate, reliable, and suitable for tracing the amount of target products during the catalytic oxidation reaction of phenol. The results can provide data support for evaluating the properties of catalysts, and, thus, guide the selection of catalysts for the industrial production of dihydric phenol. |
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