Transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanenitriles into amides and acids |
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Authors: | I V Ukrainets O V Gorokhova K V Andreeva |
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Institution: | 1354. National University of Pharmacy, ul. Pushkinskaya 53, Kharkiv, 61002, Ukraine
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Abstract: | A mixture of hydrochloric and acetic acids depleted in water was proposed to effect stepwise transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanenitriles into the corresponding amides and then into the acids. The procedure turned out to be efficient with 3-(2-phenylethyl)-carbamoyl] derivatives, whereas the reactions with benzylcarbamoyl analogs were accompanied by partial or complete debenzylation. |
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