OH functionalized Multi-Walled Carbon Nanotube modified electrode as electrochemical sensor for the detection of Aceclofenac |
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Authors: | Vinay M M Purushothama H T Yathisha R O Basavarajappa K V Manjunatha P |
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Institution: | Department of Chemistry, School of Chemical Science, Kuvempu University, Shankaraghatta, India |
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Abstract: | ABSTRACTThe rapid electrochemical determination of Aceclofenac (ACF) has been employed by cyclic voltammetry (CV), differential pulse voltammetry (DPV) using developed OH-functionalised multiwalled carbon nanotube carbon paste electrode (OH-MWCNT/CPE). Modified electrode was characterised by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), X-ray diffraction spectroscopy (XRD), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The ACF exhibits two oxidation peaks at +0.4 V, +0.66 V and one reduction peak at +0.3 V. The active surface area of the bare carbon paste electrode (BCPE) and modified electrode have been characterised by using K3Fe(CN)6] solution containing 0.1 M KCl. In DPV mode, variation of ACF gave the limit of detection (LOD = 3s/m) 0.246 μM over the concentration range 1.0 to 190.0 μM (R2 = 0.9994). The developed electrode has good stability, reproducibility and could be successfully validated for the detection of ACF in pharmaceutical samples and biological fluids. |
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Keywords: | Carbon paste electrode Cyclic voltammetry Differential pulse voltammetry Scanning electron microscopy |
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