(2-Pyridyl)phenyl methanol: a new reagent for metal-free reduction of nitro aromatic compounds |
| |
| Authors: | Donatella Giomi |
| |
| Affiliation: | Dipartimento di Chimica ‘Ugo Schiff’, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamenti Attivi (HeteroBioLab), Università di Firenze, Polo Scientifico e Tecnologico, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Italy |
| |
| Abstract: | As previously reported for 1-(2-pyridyl)-2-propen-1-ol, (2-pyridyl)phenyl methanol is able to react as hydrogen donor towards nitro aromatic and heteroaromatic compounds. Operating in the presence of methyl acrylate as an aza-Michael acceptor, a domino process involving reduction and conjugate addition steps allows the one pot formation of β-amino esters. The crucial role of the pyridine nucleus in making this purely thermal reactivity of carbinols possible has been shown. |
| |
| Keywords: | Pyridyl carbinols Hantzsch ester 1,4-dihydropyridine mimics Nitro derivatives Metal-free reductions |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
