<Emphasis Type="Italic">lin-12</Emphasis> Notch functions in the adult nervous system of <Emphasis Type="Italic">C. elegans</Emphasis> |
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| Authors: | Michael?Y?Chao Jonah?Larkins-Ford Tim?M?Tucey Email author" target="_blank">Anne?C?HartEmail author |
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| Institution: | (1) Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA;(2) Department of Pathology, Harvard Medical School, Boston, MA, USA |
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| Abstract: | Background Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during
embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation
of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. |
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