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Perthamides C-F, potent human antipsoriatic cyclopeptides |
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| Authors: | Carmen FestaSimona De Marino Valentina SepeMaria Valeria D’Auria Giuseppe BifulcoRosa Andrés Maria Carmen TerencioMiguel Payá Cécile DebitusAngela Zampella |
| Institution: | a Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II”, via D. Montesano 49, 80131 Napoli, Italy b Dipartimento di Scienze Farmaceutiche, Università di Salerno, via Ponte don Melillo, 84084 Fisciano (SA), Italy c Department of Pharmacology, University of Valencia and Center of Molecular Recognition and Technological Development (IDM), Av. V. Andrés Estelles, s/n 46100 Burjassot, Valencia, Spain d Institut de Recherche pour le Developpement (IRD), Polynesian Research Center on Island Biodiversity, BP529, 98713 Papeete, Tahiti, French Polynesia, France |
| Abstract: | Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an unprecedented β-amino acid unit (AHMOA), were determined by interpretation of NMR and MS data. The absolute configuration of the AHMOA residue was proposed on the basis of quantum chemical calculation of NMR chemical shifts. Perthamides were proved to inhibit TNF-α and IL-8 release in primary human keratinocytes cells and therefore could represent potentially leads for the treatment of psoriasis. |
| Keywords: | Marine compounds Cyclic peptides Theonella swinhoei Anti-Inflammatory activity |
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