| The Synthesis of α-DDB, β-DDB and Theoretical Study with AM1 |
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| 作者姓名： | Rui Yun GUO1 Jun Biao CHANG1* Rong Feng CHEN1 Jing Xi XIE2 Da Yu YAN3 1Henan Institute of Chemistry Zhengzhou 450002 2Institute of Meteria Medica Chinese Academy of Medical Science Beijing 100050 3The Graduate School of University of Science and T |
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| 作者单位： | Rui Yun GUO1,Jun Biao CHANG1*,Rong Feng CHEN1,Jing Xi XIE2,Da Yu YAN3 1Henan Institute of Chemistry,Zhengzhou 450002 2Institute of Meteria Medica,Chinese Academy of Medical Science,Beijing 100050 3The Graduate School of University of Science and T |
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| 基金项目： | the Henan Outstanding Younth and Natural Science Foundation of China |
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| 摘 要： | Biphenyl units are present in a wide range of compounds both natural and synthetic, and many of them have pharmacological activity1. Xie Jingxi et al. found that dimethyl 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate((-DDB) as an important intermediate for the synthesis of Schizandrin C analogue which is effective in lowering elevated SGPT level2-3. Two isomers dimethyl 6,6'-dimethoxy-4,5,4',5'-dimethylenedioxybiphenyl-2,2'-dicarboxylate ((-DDB) and 6,4,-dimethoxy-4…
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