Quantitative analysis of morphine and noscapine using corona discharge ion mobility spectrometry with ammonia reagent gas

Morphine and noscapine were determined using corona discharge ion mobility spectrometry. The detection limits were 5.6 × 10⁻¹¹ and 6.7 × 10⁻¹¹ g for morphine and noscapine, respectively. The linear dynamic ranges of the calibration plots for the compounds were about three orders of magnitude. The method has also been successfully applied for simultaneous determination of the compounds using the standard addition method.