PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media |
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| Authors: | Jin-Heng Li Xi-Chao Hu Yun Liang Ye-Xiang Xie |
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| Institution: | College of Chemistry and Chemical Engineering, Human Normal University, Changsha 410081, China |
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| Abstract: | PEG-400 poly(ethylene glycol-400)] was found to improve the Pd(OAc)2/DABCO-catalyzed aqueous Suzuki-Miyaura and Stille cross-coupling reactions. In the presence of Pd(OAc)2, DABCO, and PEG-400, a variety of aryl halides were coupled with arylboronic acids or organotin compounds efficiently to afford the corresponding cross-coupled products in moderate to excellent yields. The turnover numbers was up to 900,000 for the Suzuki-Miyaura reaction and up to 9800 for the Stille reaction. The catalyst system was also effective for Heck and Sonogashira cross-coupling reactions to some extent. |
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| Keywords: | PEG-400 Pd(OAc)2/DABCO Cross-coupling reaction Aryl halide Arylboronic acids Organotin compounds |
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