Selective syntheses of benzoxazoles and N-(2-hydroxyaryl)pyrrolidin-2-ones from the corresponding cyclopropyl amides with PPh3/CX4 |
| |
| Authors: | Yong-Hua Yang |
| |
| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China |
| |
| Abstract: | Benzoxazoles 2 can be smoothly synthesized by treatment of starting materials of N-(2-hydroxyaryl) cyclopropyl amides 1 with PPh3/CCl4 in acetonitrile in good yields. When PPh3/CBr4/MS 4 Å was used in the reaction system, the corresponding ring-expanding products 3 were obtained in moderate to good yields in acetonitrile at 80 °C. Using DCE as a solvent in this reaction, the corresponding 2-(3-chloropropyl)benzoxazoles 5 were obtained as major products. |
| |
| Keywords: | Cyclopropyl amide Benzoxazole Triphenylphosphine Tetrahalomethane Cyclopropane Ring-expanding reaction Ring-opening reaction Pyrrolidin-2-one |
| 本文献已被 ScienceDirect 等数据库收录！ |
