An electroanalytical study of the drug proflavine |
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Authors: | Stella Th Girousi Despina K Alexiadou Andrea K Ioannou |
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Institution: | (1) Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University, Thessaloniki, Greece |
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Abstract: | A square wave adsorptive stripping voltammetric (SWAdSV) method was developed for the determination of proflavine. The electrochemical
behaviour of proflavine was investigated by cyclic (CV) and square wave voltammetry (SWV) at the hanging mercury drop electrode
(HMDE) and carbon paste electrode (CPE). Different parameters were tested to optimize the conditions of the determination.
Better results were obtained by square wave voltammetry using CPE where two oxidation and a reduction peak, appeared, at 0.19,
0.94 and 0.20 V, respectively. The peak at 0.19 V is quasi-reversible and deposition dependent. Linearity was observed in
the range of (0.2–23.4) × 10−8 M (r = 0.998) during the anodic scan and in the range of (1.17–117) × 10−8 M (r = 0.999) during the cathodic scan. The second peak at 0.94 V is irreversible and deposition independent. The linearity of
this peak was observed in the range of (1.29–11.7) × 10−8 M (r = 0.998). The method was applied to the analysis of bovine serum and gave satisfactory results.
Correspondence: S. Th. Girousi, Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University, Thessaloniki
54124, Greece |
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Keywords: | : Proflavine square wave adsorptive stripping voltammetry carbon paste electrode hanging mercury drop electrode |
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