Asymmetric synthesis of 2-substituted piperidines using a multi-component coupling reaction: rapid assembly of (S)-coniine from (S)-1-(1-phenylethyl)-2-methyleneaziridine |
| |
| Authors: | Hayes J F Shipman M Twin H |
| |
| Affiliation: | GlaxoSmithKline, Old Powder Mills, Tonbridge, Kent, UK TN11 9AN. |
| |
| Abstract: | (S)-Coniine is made using a reaction which assembles the piperidine ring by the sequential formation of four new chemical bonds and installs the C-2 stereogenic centre with high levels of diastereocontrol (90% de). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
