Asymmetric synthesis of 2-substituted piperidines using a multi-component coupling reaction: rapid assembly of (S)-coniine from (S)-1-(1-phenylethyl)-2-methyleneaziridine |
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| Authors: | Hayes J F Shipman M Twin H |
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| Institution: | GlaxoSmithKline, Old Powder Mills, Tonbridge, Kent, UK TN11 9AN. |
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| Abstract: | (S)-Coniine is made using a reaction which assembles the piperidine ring by the sequential formation of four new chemical bonds and installs the C-2 stereogenic centre with high levels of diastereocontrol (90% de). |
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