Total Synthesis of Hapalindole‐Type Natural Products |
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| Authors: | Zhaohong Lu Ming Yang Pengxi Chen Xiaochun Xiong Prof. Dr. Ang Li |
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| Affiliation: | State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China) |
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| Abstract: | A unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12‐epi‐hapalindole Q isonitrile, hapalonamide H, deschloro 12‐epi‐fischerindole I nitrile, and deschloro 12‐epi‐fischerindole W nitrile, as well as the structural revision of the latter. Hapalindoles H and Q were also synthesized. |
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| Keywords: | hapalindole indole terpenoids Prins cyclization |
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