Asymmetric Gold‐Catalyzed Lactonizations in Water at Room Temperature |
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| Authors: | Dr Sachin Handa Daniel J Lippincott Donald H Aue Prof Bruce H Lipshutz |
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| Institution: | Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106 (USA) |
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| Abstract: | Asymmetric gold‐catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ‐formed aqueous nanomicelles gives good to excellent ee’s of product lactones. In‐flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process. |
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| Keywords: | asymmetric catalysis gold catalysis micellar catalysis surfactants |
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