| 聚肽接枝共聚物的自组装行为研究 |
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| 引用本文： | 陈涛,汤冬梅,林嘉平,朱国全,章苏宁,田晓慧. 聚肽接枝共聚物的自组装行为研究[J]. 高等学校化学学报, 2005, 26(5): 988-990 |
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| 作者姓名： | 陈涛 汤冬梅 林嘉平 朱国全 章苏宁 田晓慧 |
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| 作者单位： | 华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室, 上海200237 |
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| 基金项目： | 国家自然科学基金;高等学校博士学科点专项科研项目;上海市纳米科技专项基金 |
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| 摘 要： | Polymeric micelles of poly(γ-benzyl L-glutamate)(PBLG)-poly(ethylene oxide)(PEO) graft copolymer were prepared by the dialysis method in deionized water. Fluorescence spectroscopy, nuclear magnetic resonance(NMR) and transmission electron microscope(TEM) were used for the investigation of the self-assembly of PBLG-PEO graft copolymer. Fluorescence spectrosco0y measurements suggest that PBLG-PEO graft copolymer associates to form polymeric micelles in water. ^1H NMR measurements further prove that in aqueous medium PBLG-PEO graft copolymer could assemble into polymeric micelles with PBLG segments as the hydrophobic inner core and PEO segments as the hydrophilic shell. The results of the TEM observations show that the polymeric micelles of PBLG-PEO graft copolymer are almost spindly shaped, which are different from the morphology of the spherical micelles formed by PBLG-PEO block copolymer. Polymeric micelles formed by polypeptide copolymer have potential application as drug carrier in controlled-release delivery system.
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| 关 键 词： | 聚肽 接枝共聚物 自组装 胶束 荧光 |
| 文章编号： | 0251-0790(2005)05-0988-03 |
| 收稿时间： | 2004-05-24 |
Self-assembly Behavior of Polypeptide Graft Copolymer |
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| CHEN Tao,TANG Dong-mei,LIN Jia-ping,ZHU Guo-Quan,ZHANG Sun-Ning,TIAN Xiao-hui. Self-assembly Behavior of Polypeptide Graft Copolymer[J]. Chemical Research In Chinese Universities, 2005, 26(5): 988-990 |
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| Authors: | CHEN Tao TANG Dong-mei LIN Jia-ping ZHU Guo-Quan ZHANG Sun-Ning TIAN Xiao-hui |
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| Affiliation: | School of Materials Science and Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Polymeric micelles of poly(γ-benzyl L-glutamate)(PBLG)-poly(ethylene oxide)(PEO) graft copolymer were prepared by the dialysis method in deionized water. Fluorescence spectroscopy, nuclear magnetic resonance(NMR) and transmission electron microscope(TEM) were used for the investigation of the self-assembly of PBLG-PEO graft copolymer. Fluorescence spectrosco0y measurements suggest that PBLG-PEO graft copolymer associates to form polymeric micelles in water. 1H NMR measurements further prove that in aqueous medium PBLG-PEO graft copolymer could assemble into polymeric micelles with PBLG segments as the hydrophobic inner core and PEO segments as the hydrophilic shell. The results of the TEM observations show that the polymeric micelles of PBLG-PEO graft copolymer are almost spindly shaped, which are different from the morphology of the spherical micelles formed by PBLG-PEO block copolymer. Polymeric micelles formed by polypeptide copolymer have potential application as drug carrier in controlled-release delivery system. |
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| Keywords: | Polypeptide Graft copolymer Self-assembly Micelle Fluorescence |
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