Synthesis of benzimidazolone derivatives based on 2-acylcyclohexane-1,3-diones alkoximes |
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Authors: | D B Rubinov T A Zheldakova I L Rubinova F A Lakhvich |
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Institution: | (1) Insitute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus |
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Abstract: | 2-(1-Alkoxyiminoalkyl)cyclohexane-1,3-diones undergo at heating Beckmann rearrangement to give 6,7-dihydro-1,3-benzoxazol-4(5H)-one derivatives that under treatment with amines in acid medium are converted into 1,5,6,7-tetrahydro-4H-benzimidazol-4-ones. In reaction of 6,7-dihydro-1,3-benzoxazol-4(5H)-ones with O-ethylhydroxylamine 4-ethoxyimino derivatives were obtained that treated with hydrochloric acid formed the corresponding N-ethoxybenzimidazolones. |
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