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Synthesis, Characterization and Antimicrobial Study of a New Schiff Base Paeonol-phenylpropanolamine
作者姓名:许同桃  许兴友  高健  刘兰蕾  倪帅帅  陆路德  杨绪杰
作者单位:[1]Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, China [2]Materials Chemistry Laboratory, Natging University of Science & Technology, Nanjing 210094, China [3]Depa ment of Chemteal Engineering, Llanyungang Teehmcal College, Lianyungang 222006, China
摘    要:


Synthesis, Characterization and Antimicrobial Study of a New Schiff Base Paeonol-phenylpropanolamine
XU Tong-Tao,XU Xing-You,GAO Jian,LIU Lan-Lei,NI Shuai-Shuai,LU Lu-De,YANG Xu-Jie.Synthesis, Characterization and Antimicrobial Study of a New Schiff Base Paeonol-phenylpropanolamine[J].Chinese Journal of Structural Chemistry,2006,25(12):1502-1506.
Authors:XU Tong-Tao  XU Xing-You  GAO Jian  LIU Lan-Lei  NI Shuai-Shuai  LU Lu-De  YANG Xu-Jie
Abstract:A novel Schiff base compound was synthesized by the reaction of paeonol and phenylpropanolamine in absolute methanol. It was characterized by elemental analyses, IR, 1H NMR and X-ray single-crystal diffraction. The compound crystallizes in the triclinic system, space group P-1, with a =6.4075(11), b = 10.2821(18), c = 12.573(2)(A), α = 92.606(3),β = 100.980(3), γ = 90.994(3)°, V= 812.1(2)(A)3, Mr = 299.36, Z = 2, F(000) = 320, Dc = 1.224 g/cm3, T= 293(2) K,μ= 0.083 mm-1 and λ = 0.71073 (A),the final R = 0.0555 and wR = 0.1619 for 2442 observed reflections with I>2σ(I). The compound was valued for its antirnicrobial activity against bacterial strands using the agar diffusion method. It is found to be active against Candida albicans and Staphylococcus aureus.
Keywords:phenylpropanolamine  paeonol  crystal structure  antimicrobial activity
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