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Synthesis of novel analogues of zanamivir as neuraminidase inhibitors |
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| Authors: | Rui Sheng Xiong Qing Jie Zhao Hang Hang Zhu Zheng Liu Ya Bing Wei Jing Shan Shen |
| Affiliation: | a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;b College of Materials Science and Engineering, Nanjing University of Technology, Nanjing 210009, China;c Topharman Shanghai Co., Ltd., Shanghai 201209, China |
| Abstract: | A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was described. The formation of amides from the acid with corresponding amines, followed by click chemistry generated the triazole substituted compounds as novel analogues of neuraminidase inhibitors in good yields. |
| Keywords: | Zanamivir Triazole Click chemistry |
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