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Breast cancer detection by Fourier transform infrared spectrometry |
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| Authors: | Marc Meurens Joëlle Wallon Jiashu Tong Henri Noël Jules Haot |
| Institution: | a Laboratoire de Spectrométrie Infrarouge, Université Catholique de Louvain, Place Croix du Sud 2 / 8, 1348, Louvain-la-Neuve, Belgium b Service d'Anatomie Pathologique, Cliniques Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10 / 1712, 1200, Brussels, Belgium c Anatomie Pathologique, A.N.A.P. Rue A. Lambiotte 144, 1030, Brussels, Belgium d Service d'Anatomie Pathologique, Hôpital Erasme, Route de Lennik 808, 1070, Brussels, Belgium |
| Abstract: | Fourier transform infrared spectra of 75 biopsies from 55 cases of breast carcinoma were studied in comparison with histo-morphometry. The spectra of carcinomatous tissues are very different from those of normal tissues. There are evident correlations between the intensity of some infrared absorption bands and the volume density of malignant cells measured by optical microscopy 7]. Very high correlation coefficients are observed for phosphate monoester and phosphodiester bands; significant correlation coefficients are also observed for amide I and II bands. |
| Keywords: | Infrared spectrometry Fourier transform Breast cancer Volume density Malignant cells |
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