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Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives |
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| Authors: | Xiao Ming Zha Fei Ran Zhangc Jia Qi Shana Yi Hua Zhanga Jun OLiu Hong Bin Sun a Center for Drug Discovery School of Pharmacy China Pharmaceutical University Nanjing China b Jiangsu Center for Drug Screening China c |
| Institution: | a Center for Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;b Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China;c Department of Pharmacology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA |
| Abstract: | Solasodine 11 is a steroidal alkaloid with various biological activities. Herein, 8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro. Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs. In particular, 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50 = 3.91μmol/L). |
| Keywords: | Solasodine Derivatives in vitro Anticancer |
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