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Facile synthesis of thermo- and pH-responsive biodegradable microgels |
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| Authors: | Changwen Zhao Xiaoye Gao Pan He Chunsheng Xiao Xiuli Zhuang Xuesi Chen |
| Institution: | (1) Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of China;(2) Graduate School of Chinese Academy of Sciences, Beijing, 100039, People’s Republic of China; |
| Abstract: | A novel and facile strategy has been designed to prepare biodegradable microgels with thermo- and pH-responsive property. The microgels were synthesized by the crosslinking of N-isopropylacrylamide with vinyl groups functionalized poly(L-glutamic acid) (PGA). The resultant microgels exhibited pH-dependent phase transition behaviors in aqueous solutions and underwent abrupt lower critical solution temperature decrease when the pH was reduced below the pK a of PGA. Dynamic light scattering measurement revealed that the microgels exhibited shrinkage as the temperature increased or the pH decreased. |
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