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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
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| Authors: | Kailey A. Wyman Adel S. Girgis Pragnakiran S. Surapaneni Jade M. Moore Noura M. Abo Shama Sara H. Mahmoud Ahmed Mostafa Reham F. Barghash Zou Juan Radha D. Dobaria Ahmad J. Almalki Tarek S. Ibrahim Siva S. Panda |
| Affiliation: | 1.Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA;2.Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt;3.Schulich School of Medicine and Dentistry, Western University, London, ON N6A5C1.1, Canada;4.Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt;5.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia |
| Abstract: | We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies. |
| Keywords: | quinoline indole rhodanine SARS-CoV-2 molecular modeling healthcare |