A Concise Synthesis of Sacidumlignan B |
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| Authors: | Zhiyuan Zhuang Zhenbiao Luo Sichen Yao Yawen Wang Yu Peng |
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| Affiliation: | 1.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;2.Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | ![]()
A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in this 2,7′-cyclolignan natural product. |
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| Keywords: | cyclolignan total synthesis cyclization synthetic efficiency Barbier reaction |
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