A scalable synthesis of a histamine H3 receptor antagonist |
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| Authors: | Mani Neelakandha S Jablonowski Jill A Jones Todd K |
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| Affiliation: | Department of Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA. nmani@prdus.jnj.com |
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| Abstract: | ![]()
Starting from 1-methylimidazole, a concise, scalable, three-step synthesis of the title compound is described. The required 2-chloroimidazole was prepared in very good yield by halogen-metal exchange between the 2-lithio derivative and hexachloroethane. |
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