Determination of mitomycin C in human blood plasma and urine by high-performance differential pulse polarography |
| |
| Authors: | W.P. van Bennekom U.R. Tjaden E.A. de Bruijn A.T. van Oosterom |
| |
| Affiliation: | Department of Pharmaceutical Analysis and Analytical Chemistry, Subfaculty of Pharmacy of the University of Leiden, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden The Netherlands;Leiden University Medical Center, Department of Pharmacology, Leiden The Netherlands;Leiden University Medical Center, Department of Clinical Oncology, Leiden The Netherlands |
| |
| Abstract: | ![]()
High-performance differential pulse polarography is used for determining the antitumor antibiotic mitomycin C in human blood plasma and urine. The limit of determination (2-ml samples) is 25 ng ml?1 when the substance is isolated by means of Amberlite XAD-2, and 200 ng mo?1 when samples are not pretreated. The method was applied in a pharmacokinetic experiment; no metabolites of mitomycin C were observed in urine or plasma. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
