Comparative evaluation of two substrates for urinary determination of p-aminobenzoic acid by room-temperature phosphorimetry |
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| Authors: | HThomas Karnes SG Schulman JD Winefordner |
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| Institution: | College of Pharmacy, University of Florida, Box J-4, J. Hillis Miller Health Center, Gainesville, FL 32611 U.S.A.;Department of Chemistry, University of Florida, Gainesville, FL 32611 U.S.A. |
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| Abstract: | Filter paper (S & S 903) impregnated with diethylenetriaminopentaacetic acid, and Whatman DE-81 anion-exchange paper are evaluated for quantitation of urinary p-aminobenzoic acid. The two substrates are compared with respect to drying characteristics, pH variations, heavy atom effect, and some other variables. Impregnated S & S 903 paper is superior in terms of drying characteristics and background interferences but DE-81 has several advantages including lower detection limit, wider pH range, and ready availability. Although both substrates seem applicable to clinical application, DE-81 is probably more useful. |
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