| Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson＇s Disease |
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| 作者姓名： | ZHANG Lin-bo LIU Xiao-hua JIANG Yuan GUO Ping SHA Li-jin LI Yu |
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| 作者单位： | [1]Institute of Mycology [2]College of Biotechnology,Jilin Agricultural University, Changchun 130118, P. R. China |
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| 基金项目： | Supported by the Natural Science Foundation of Jilin Province（ No. 20030224-2） and the Doctor Priming Foundation of Jilin Agricultural University （ 2004-2006 ）. |
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| 摘 要： | After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experiments with notoginsenoside-Rg1 were carried out. The research results show that the expressions of GFAP, NF-Kκ and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons. The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats. The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network. Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson＇s disease（PD）.
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| 关 键 词： | 帕金森病 Notoginsenoside-Rg1 神经免疫分子网络 蛋白质 治疗方法 |
| 文章编号： | 1005-9040（2006）-02-139-06 |
| 收稿时间： | 2005-12-31 |
Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson's Disease |
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| ZHANG Lin-bo LIU Xiao-hua JIANG Yuan GUO Ping SHA Li-jin LI Yu.Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson''s Disease[J].Chemical Research in Chinese University,2006,22(2):139-144. |
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| Authors: | Lin-bo ZHANG Xiao-hua LIU Yuan JIANG Ping GUO Li-jin SHA Yu LI |
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| Institution: | aInstitute of Mycology, Jilin Agricultural University, Changchun 130118, P. R. China;bCollege of Biotechnology, Jilin Agricultural University, Changchun 130118, P. R. China |
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| Abstract: | |
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| Keywords: | Parkinson's disease Notoginsenoside-Rg1 Neuro-immune molecular network |
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