Platelet‐Facilitated Photothermal Therapy of Head and Neck Squamous Cell Carcinoma |
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| Authors: | Lang Rao Dr. Lin‐Lin Bu Dr. Liang Ma Dr. Wenbiao Wang Huiqin Liu Da Wan Jian‐Feng Liu Andrew Li Prof. Shi‐Shang Guo Prof. Lu Zhang Prof. Wen‐Feng Zhang Prof. Xing‐Zhong Zhao Prof. Zhi‐Jun Sun Prof. Wei Liu |
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| Affiliation: | 1. Key Laboratory of, Artificial Micro- and Nano-Structures of, Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, P. R. China;2. State Key Laboratory Breeding Base of, Basic Science of Stomatology, Key Laboratory of Oral Biomedicine of, Ministry of Education, Department of Oral Maxillofacial Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, P. R. China;3. College of Life Sciences, Wuhan University, Wuhan, P. R. China;4. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, USA |
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| Abstract: | Here, we present a platelet‐facilitated photothermal tumor therapy (PLT‐PTT) strategy, in which PLTs act as carriers for targeted delivery of photothermal agents to tumor tissues and enhance the PTT effect. Gold nanorods (AuNRs) were first loaded into PLTs by electroporation and the resulting AuNR‐loaded PLTs (PLT‐AuNRs) inherited long blood circulation and cancer targeting characteristics from PLTs and good photothermal property from AuNRs. Using a gene‐knockout mouse model, we demonstrate that the administration of PLT‐AuNRs and localizing laser irradiation could effectively inhibit the growth of head and neck squamous cell carcinoma (HNSCC). In addition, we found that the PTT treatment augmented PLT‐AuNRs targeting to the tumor sites and in turn, improved the PTT effects in a feedback manner, demonstrating the unique self‐reinforcing characteristic of PLT‐PTT in cancer therapy. |
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| Keywords: | cancer therapy drug delivery nanomedicine photothermal therapy platelets |
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