Site‐Selective Linear Alkylation of Anilides by Cooperative Nickel/Aluminum Catalysis |
| |
| Authors: | Shogo Okumura Takuya Komine Erika Shigeki Prof?Dr Kazuhiko Semba Prof?Dr Yoshiaki Nakao |
| |
| Institution: | Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Japan |
| |
| Abstract: | We report meta‐ and para‐selective linear alkylation reactions of anilides with alkenes by nickel/N‐heterocyclic carbene (NHC) and aluminum catalysis. With a less bulky NHC, the alkylation reaction of N‐methyl‐N‐phenylcyclohexanecarboxamides proceeded mainly at the meta position. In contrast, a bulky NHC ligand led to the para‐selective alkylation of N‐sec‐alkyl anilides. |
| |
| Keywords: | alkenes aluminum C− H functionalization cooperative catalysis nickel |
|
