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Novel nanostructured electrochemical sensor for voltammetric determination of N-acetylcysteine in the presence of high concentrations of tryptophan |
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| Authors: | Masoud Fouladgar Hassan Karimi-Maleh Rahman Hosseinzadeh |
| Institution: | 1. Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Falavarjan, Iran 2. Department of Chemistry, Science and Research Branch, Islamic Azad University, Mazandaran, Iran 3. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran |
| Abstract: | A carbon paste electrode chemically modified with multiwall nanotubes and ethynylferrocene (ETFc) was used as a selective and sensitive electrochemical sensor for the determination of minor amounts of N-acetylcysteine (N-AC) in the presence of a high concentration of tryptophan (Trp). Square wave voltammetry (SWV) of N-AC at the modified electrode exhibited linear dynamic range with a detection limit (3 s) of 0.08 μmol?L?1. The separations of anodic peak potentials of N-AC and Trp reached 400 mV using SWV. With good selectivity and sensitivity, the present method provides a simple method for selective detection of N-AC in real samples such as drug and urine. |
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