An effective procedure for the acylation of azaindoles at C-3 |
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| Authors: | Zhang Zhongxing Yang Zhong Wong Henry Zhu Juliang Meanwell Nicholas A Kadow John F Wang Tao |
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| Affiliation: | Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. |
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| Abstract: | Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl(3) in CH(2)Cl(2) followed by the addition of an acyl chloride at room temperature. |
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