| Construction of Recombinant Modified Vaccinia Ankara （MVA） Expressing Hepatitis B Virus Surface Antigen |
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| 作者姓名： | CHEN Yu YANG Xiao-song YU Xiang-hui JIANG Chun-lai WU Yong-ge JIN Ying-hua CHEN Yue CHEN Yan LI Wei KONG Wei |
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| 作者单位： | CHEN Yu，YANG Xiao-song，YU Xiang-hui，JIANG Chun-lai，WU Yong-ge，JIN Ying-hua，CHEN Yue，CHEN Yan，LI Wei and KONG Wei*Vaccine Research Center，College of Life Science，Jilin University，Changchun 130012，P. R. China |
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| 摘 要： | Introduction Despitetheexistenceofeffectiveprophylacticvac cinesagainstthehepatitisBvirus(HBV)formany years,HBVinfectionremainsaserioushealthproblem worldwide.Approximatetwobillionpeoplehavebeen infectedbyHBVanditisestimatedthatmorethan350millionofthemare…
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| 关 键 词： | 重组细胞MVA 牛痘 治疗疫苗 T淋巴细胞 病毒传染 表面抗原 |
| 文章编号： | 1005-9040（2006）-02-213-04 |
| 收稿时间： | 2005-12-31 |
Construction of Recombinant Modified Vaccinia Ankara (MVA) Expressing Hepatitis B Virus Surface Antigen |
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| CHEN Yu YANG Xiao-song YU Xiang-hui JIANG Chun-lai WU Yong-ge JIN Ying-hua CHEN Yue CHEN Yan LI Wei KONG Wei.Construction of Recombinant Modified Vaccinia Ankara (MVA) Expressing Hepatitis B Virus Surface Antigen[J].Chemical Research in Chinese University,2006,22(2):213-216. |
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| Authors: | Yu CHEN Xiao-song YANG Xiang-hui YU Chun-lai JIANG Yong-ge WU Ying-hua JIN Yue CHEN Yan CHEN Wei LI Wei KONG |
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| Institution: | aVaccine Research Center, College of Life Science, Jilin University, Changchun 130012, P. R. China |
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| Abstract: | The T lymphocyte response has been shown to be the determinant in the clearance of many viral infections. Hence, therapeutic vaccine candidates against HBV are designed to enhance this response of the immune system. Vaccinia virus vector-based vaccines have been proposed as excellent candidates to elicit long-term and strong T lymphocyte mediated immune responses. In this study, the recombinant MVA expressing HBV surface antigen has been constructed, which can elicit a potent T cell mediated response. The ELISA results for the surface protein in the medium of the recombinant MVA, strongly indicate that the recombinant virus has been successfully obtained. |
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| Keywords: | Recombinant MVA Therapeutic vaccine T lymphocyte response |
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