Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclization |
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| Authors: | Xiao Bin Gong Tian-Jun Liu Zhao-Jing Liu Jing-Hui Luo Dong-Fen Xu Jun Liu Lei |
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| Affiliation: | Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China. |
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| Abstract: | A practical, Pd(0)/Pd(II)-catalyzed reaction was developed for phenol-directed C-H activation/C-O cyclization using air as an oxidant. The turnover-limiting step of the process was found to be C-O reductive elimination instead of C-H activation. This reaction can tolerate a variety of functional groups and is complementary to the previous methods for the synthesis of substituted dibenzofurans. |
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