|
|||||
|
|
Cuprate-catalyzed Three-Component Couplings of Functionalized Organozinc Reagents |
|
| Authors: | Bruce H. Lipshutz Tim Gross Daniel J. Buzard Raymond Tirado |
| Abstract: | Organozinc reagents FG-(CH2)nZnX containing electrophilic centers (FG) upon conversion to their corresponding zincates (FG-(CH2)nZnMe2Li) and in the presence of 5–8 mol % MeCu(CN)Li, undergo 1,4-additions to cyclic conjugated enones. The intermediate zinc enolates can be trapped with aldehydes to afford products of three-component couplings. |
| Keywords: | |