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Cancer therapy with drug loaded magnetic nanoparticles—magnetic drug targeting |
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| Authors: | Christoph Alexiou Rainer TietzeEveline Schreiber Roland JurgonsHeike Richter Lutz TrahmsHelene Rahn Stefan OdenbachStefan Lyer |
| Institution: | a Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine at the Else Kröner-Fresenius-Stiftung-Professorship, Germany b Franz Penzoldt Center, University Hospital Erlangen, Germany c PTB Berlin, Germany d TU Dresden, Chair of Magnetofluiddynamics, 01062 Dresden, Germany |
| Abstract: | The aim of magnetic drug targeting (MDT) in cancer therapy is to concentrate chemotherapeutics to a tumor region while simultaneously the overall dose is reduced. This can be achieved with coated superparamagnetic nanoparticles bound to a chemotherapeutic agent. These particles are applied intra arterially close to the tumor region and focused to the tumor by a strong external magnetic field. The interaction of the particles with the field gradient leads to an accumulation in the region of interest (i.e. tumor). The particle enrichment and thereby the drug-load in the tumor during MDT has been proven by several analytical and imaging methods. Moreover, in pilot studies we investigated in an experimental in vivo tumor model the effectiveness of this approach. Complete tumor regressions without any negative side effects could be observed. |
| Keywords: | Cancer treatment Nanoparticle Local chemotherapy |
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