Base-catalyzed cyclization reaction of 2-chloroquinoline-3-carbonitriles and guanidine hydrochloride: a rapid synthesis of 2-amino-3H-pyrimido[4,5-b]quinolin-4-ones |
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Authors: | Atish ChandraShraddha Upadhyay Bhawana SinghNeha Sharma Radhey M Singh |
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Institution: | Department of Chemistry, Centre of Advance Studies, Banaras Hindu University, Varanasi, U.P., India |
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Abstract: | t-BuOK-catalyzed cyclization of 2-chloroquinoline-3-carbonitriles with guanidine hydrochloride provided simple and rapid synthesis of 2-amino-3H-pyrimido4,5-b]quinolin-4-ones in very short reaction time with good yield. Other 1,3-binucleophiles are found to react at the same rate. This methodology could be extended with their 3-formyl and 3-ester derivatives for the synthesis of pyrimido annulated quinolines. |
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Keywords: | Pyrimidoquinoline 2-Chloroquinoline-3-carbonitrile Base-catalyzed Guanidine hydrochloride |
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