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Synthesis and Characterization of Ordered Mesoporous Silica Spheres Using Anionic and Nonionic Mixed Surfactants for Their Potential Application in LC |
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| Authors: | Weiqiang Hao Bin Di Hui Liu Taijun Hang Fang Yan Mengxiang Su |
| Affiliation: | 3. High-Tech Research Institute of Nanjing University, Changzhou, 213164, China 1. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, 210009, China 2. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing, 210009, China |
| Abstract: | Ordered mesoporous silicas (OMSs) with spherical morphology were synthesized by using mixed surfactants of anionic sodium dodecyl sulfate and nonionic block copolymer EO20PO70EO20 (P123) as template through an acid-catalyzed silica sol?Cgel process. A variety of characterizations demonstrated that the silica products exhibited well-formed spherical morphology, ordered mesostructure, narrow pore size distribution and large surface area (~700 m2 g?1). It was found that the synthesized OMSs had high adsorption capacity by using oxymatrine as model solute. The column packed with the silica spheres exhibited low back pressure and baseline separation of aromatic compounds such as benzene and nitrobenzene could be achieved. These results demonstrated the synthesized OMSs as a potential stationary phase for liquid chromatography. |
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