| Synthesis, Characterization of Heterodinuclear Co-Cu Complex and Its Electrocatalytic Activity towards O_2 Reduction: Implications for Cytochrome c Oxidase Active Site Modeling |
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| 作者姓名： | 卢卫兵 汪存信 周晓海 任建国 |
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| 作者单位： | College of Chemistry and Molecular Science，Wuhan University，Wuhan，Hubei 430072，China，College of Chemistry and Molecular Science，Wuhan University，Wuhan，Hubei 430072，China，College of Chemistry and Molecular Science，Wuhan University，Wuhan，Hubei 430072，China，College of Chemistry and Molecular Science，Wuhan University，Wuhan，Hubei 430072，China |
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| 基金项目： | theNationalNaturalScienceFoundationofChina (Nos .2 98710 2 4and 30 0 70 2 0 0 ) |
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| 摘 要： | IntroductionMetalloenzymesplaymanyimportantrolesinnatureespeciallyinelectron transferbiologicalprocesses .Be causeoftheirimportanceandcomplexity ,manysimplifiedmodelsystemshavebeenconstructedforthestudyoftheirchemistry .Amongvariouspolymetallicmetalloenzymes ,cytochromecoxidase (CcO)istheoneofthemostspecialinterest.CcO ,theterminalenzymeoftherespiratorychain ,catalyzesthereductionofO2 by 4H+,4e- towaterwith outleakageofanypartiallyreducedintermediateswhicharetoxictocellsuchasH2 O2 .Thefree…
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Synthesis, Characterization of Heterodinuclear Co-Cu Complex and Its Electrocatalytic Activity towards O_2 Reduction: Implications for Cytochrome c Oxidase Active Site Modeling |
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| LU,Wei-Bing WANG,Cun-Xin ZHOU,Xiao-Hai REN,Jian-Guo College of Chemistry and Molecular Science,Wuhan University,Wuhan,Hubei ,China.Synthesis, Characterization of Heterodinuclear Co-Cu Complex and Its Electrocatalytic Activity towards O_2 Reduction: Implications for Cytochrome c Oxidase Active Site Modeling[J].Chinese Journal of Chemistry,2003(9). |
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| Authors: | LU Wei-Bing WANG Cun-Xin ZHOU Xiao-Hai REN Jian-Guo College of Chemistry and Molecular Science Wuhan University Wuhan Hubei China |
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| Institution: | LU,Wei-Bing WANG,Cun-Xin ZHOU,Xiao-Hai REN,Jian-Guo College of Chemistry and Molecular Science,Wuhan University,Wuhan,Hubei 430072,China |
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| Abstract: | A new dinucleating ligand consisting of a tetraphenylporphyrin derivative covalently linked with tris(2-benzimidazylmethyl)-amine and its homodinuclear Co-Co and heterodinuclear Co-Cu complexes were synthesized and spectroscopically characterized. The heterobimetallic cobalt-copper complex bearing three benzimidazole ligands for copper, as cytochrome c oxidase active site model, was applied to the surface of glassy carbon electrode to show electrocatalytic activity for O 2 reduction in aqueous solution at an acidity level close to physiological pH value. The kinetic parameters of this electrocatalytic process were obtained. |
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| Keywords: | dinucleating ligand homodinuclear heterodinuclear cytochrome c oxidase structural model |
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