| N-(2-丙酸)-芳甲酰腙二对甲基苄基锡配合物的合成、晶体结构及生物活性 |
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| 引用本文： | 张志坚,蒋伍玖,刘洋,邝代治,庾江喜,朱小明,谭宇星.N-(2-丙酸)-芳甲酰腙二对甲基苄基锡配合物的合成、晶体结构及生物活性[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 张志坚 蒋伍玖 刘洋 邝代治 庾江喜 朱小明 谭宇星 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008 |
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| 基金项目： | 湖南省自然科学基金（No.2017JJ3003，2016JJ4008，2016JJ5004）和湖南省功能金属有机材料高校重点实验室开放基金项目（No.GN16K03）资助. |
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| 摘 要： | 二对甲基苄基二氯化锡分别与N-（2-丙酸）-对硝基苯甲酰腙及N-（2-丙酸）-对叔丁基苯甲酰腙反应，合成了2个取代二苄基锡配合物（C1、C2），通过元素分析、IR、UV-Vis、1H NMR、13C NMR、119Sn NMR、X射线单晶衍射以及热重分析等表征了配合物结构。测试了配合物对癌细胞H460、HepG2、MCF7以及正常人体肝细胞HL7702的体外抑制活性；在Tris-HCl缓冲溶液中，以EB作为荧光探针，用荧光光谱法初步研究了配合物与小牛胸腺DNA的相互作用。结果表明：配合物C1、C2对3种癌细胞都有较好的抑制作用，配合物C2对HL7702的细胞毒性远小于C1；配合物C1、C2与小牛胸腺DNA作用均是插入结合作用所致。
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| 关 键 词： | 有机锡配合物 酰腙 合成 晶体结构 生物活性 |
| 收稿时间： | 2017/5/4 0:00:00 |
| 修稿时间： | 2017/8/1 0:00:00 |
Syntheses,Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes |
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| ZHANG Zhi-Jian,JIANG Wu-Jiu,LIU Yang,KUANG Dai-Zhi,YU Jiang-Xi,ZHU Xiao-Ming and TAN Yu-Xing.Syntheses,Crystal Structures and Biological Activity of N-(2-Propionic acid)-aroyl Hydrazone Di-p-methylbenzytin Complexes[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | ZHANG Zhi-Jian JIANG Wu-Jiu LIU Yang KUANG Dai-Zhi YU Jiang-Xi ZHU Xiao-Ming and TAN Yu-Xing |
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| Institution: | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China and Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Two substituted benzyltin complexes (C1,C2) has been synthesized via the reaction of N-(2-propionic acid)-aroyl hydrazone with di-p-methylbenzytin dichloride. The complexes C1 and C2 have been characterized by IR, UV-Vis, 1H NMR, 13C NMR 119Sn NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines(H460,HepG2, MCF7) and a human cell line(HL7702). Two complexes exhibit strong antitumor activity, moreover, C2 is less toxic than C1. The result of EB fluorescent probe shows the interaction between complexes and calf thymus DNA is intercalation. |
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| Keywords: | organotin complex hydrazone synthesis crystal structure biological activity |
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