Stereoselective synthesis of the C3-C15 fragment of callyspongiolide |
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| Authors: | Gopal Reddy Ramidi Jhillu S. Yadav Debendra K. Mohapatra |
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| Affiliation: | 1. Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;2. Academy of Scientific and Innovative Research (AcSIR), Mathura Road, New Delhi 110 025, India;3. School of Science, Indrashil University, Kadi, Gujarat 382740, India |
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| Abstract: | The synthesis of C3-C15 fragment of callyspongiolide, a 14-membered macrolides isolated from the marine sponge Callyspongia sp., which was collected from the Indonesia, is reported. Highlights of the synthesis include construction of E-olefin through Julia-Kocienski olefination, Brown asymmetric allylation and base-induced elimination reactions for propargyl alcohol synthesis. |
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| Keywords: | Callyspongiolide Natural products Julia-Kocienski olefination Brown asymmetric allylation Base-induced elimination reaction |
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