Chemical transformations of tetracyclo[3.3.1.13,7.01,3]decane (1,3-dehydroadamantane): II. Reaction of 1,3-dehydroadamantane with N,N-dialkylcarboxamides |
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Authors: | V. M. Mokhov G. M. Butov K. R. Saad |
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Affiliation: | 1.Volgograd State Technical University,Volgograd,Russia;2.Volzhskii Polytechnic Institute (Branch),Volgograd State Technical University,Volzhskii, Volgograd oblast,Russia |
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Abstract: | Alkylation of N,N-dialkylcarboxamides with 1,3-dehydroadamantane has been accomplished for the first time. The reaction involves the C–H bond in the α-position with respect to the carbonyl group and provides a convenient one-step preparation of substituted carboxylic acid amides containing an 1-adamantyl substituent and a pharmacophoric group in the amide moiety. |
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