Novel approach to the synthesis of istaroxime |
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| Authors: | G.-P. Liang J.-H. Guo R.-W. Jiang |
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| Affiliation: | 1.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy,Jinan University,Guangzhou, Guangdong,China |
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| Abstract: | ![]()
Istaroxime 1, a novel cardiotonic agent with high efficiency and low toxicity was synthesized from dehydroepiandrosterone 2 using a novel approach that included epoxidation, ring-opening, substitution, and oximation. The new protocol without gas protection was milder than the reported approaches. The overall yield of the method was 24.1%. |
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