Thiazonaphthalimide derivatives: Synthesis and interaction with DNA |
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| Authors: | Alexandra Botz Yves Chenavier Jacques Pécaut Pascale Delangle Christelle Gateau |
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| Institution: | Univ. Grenoble Alpes, CEA, CNRS, INAC-SyMMES, 38000 Grenoble, France |
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| Abstract: | The synthesis of several thiazonaphthalimide derivatives is described. The exclusive formation of angular rather than linear isomers was unequivocally demonstrated by NMR and single crystal X-ray diffraction. Their photophysical properties and ability to bind calf-Thymus DNA with affinities in the range of 104 makes them interesting candidates to probe DNA by fluorescence. |
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| Keywords: | DNA 1 8-Naphthalimide Thiazole formation Fluorescence |
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