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| KF-alumina 催化下2-氨基-4-芳基-5,6-二氢化-4H-吡喃[3,2-c]喹啉-5-酮-3-羧酸酯衍生物的一步合成 | |
| 引用本文： | 王香善,曾兆森,史达清,屠树江,魏贤勇,宗志敏. KF-alumina 催化下2-氨基-4-芳基-5,6-二氢化-4H-吡喃[3,2-c]喹啉-5-酮-3-羧酸酯衍生物的一步合成[J]. 有机化学, 2005, 25(5): 579-582 |
| 作者姓名： | 王香善 曾兆森 史达清 屠树江 魏贤勇 宗志敏 |
| 作者单位： | 1. 徐州师范大学化学系,徐州,221116;中国矿业大学化学工程学院,徐州,221008;江苏省药用植物生物技术重点实验室,徐州,221116 2. 徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116 3. 中国矿业大学化学工程学院,徐州,221008 |
| 基金项目： | 江苏省教育厅青蓝工程项目，江苏省高校自然科学基金 |
| 摘 要： | 以芳醛、氰乙酸酯和4-羟基喹啉-2-酮为原料, 乙醇为溶剂, 在KF-Al2O3催化下80 ℃, 一步合成了2-氨基-4-芳基-5,6-二氢化-4H-吡喃[3,2-c]喹啉-5-酮-3-羧酸酯衍生物, 和其它方法相比, 具有反应条件温和, 容易操作和产率高等优点, 产物4a的结构通过X单晶衍射分析确证. |
| 关 键 词： | 吡喃喹啉 4-羟基喹啉-2-酮 KF-Al2O3 |
| 收稿时间： | 2004-10-09 |
| 修稿时间： | 2004-04-19 |
One-step Synthesis of 2-Amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]-quino-lin-5-one-3-carboxylate Derivatives Catalyzed by KF-alumina |
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| WANG Xiang-Shan,ZENG Zhao-Sen,SHI Da-Qing,TU Shu-Jiang,WEI Xian-Yong,ZONG Zhi-Min. One-step Synthesis of 2-Amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]-quino-lin-5-one-3-carboxylate Derivatives Catalyzed by KF-alumina[J]. Chinese Journal of Organic Chemistry, 2005, 25(5): 579-582 | |
| Authors: | WANG Xiang-Shan ZENG Zhao-Sen SHI Da-Qing TU Shu-Jiang WEI Xian-Yong ZONG Zhi-Min |
| Affiliation: | ( Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)( School of Chemical Engineering, China University of Mining and Technol-ogy, Xuzhou 221008)( Key Laboratory of Biotechnology on Medical Plant, Xuzhou 221116) |
| Abstract: | A series of 2-amino-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinolin-5-one-3-carboxylate derivatives were synthesized by the reaction of arylaldehyde, cyanoacetate and 4-hydroxyl-1,2-dihydroquinolin- 2-one catalyzed by KF-Al2O3 in ethyl alcohol at 80 ℃. Compared with other synthetic methods, this new method has the advantages of easy work-up, mild reaction conditions and good yields. The structure of 4a was confirmed by X-ray analysis. |
| Keywords: | KF-Al2O3 |
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