Transition metal complexes of a hydrazone derived from hydralazine hydrochloride and 3,5-di-tert-butylsalicylaldehyde |
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| Authors: | Sunil M Patil Ramesh S Vadavi Suneel Dodamani Umashri Kendur Geeta Chimmalagi Sunil Jalalpure Christopher S Frampton Kalagouda B Gudasi |
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| Institution: | 1.Department of Chemistry,Karnatak University,Dharwad,India;2.Y. B. Annigeri Pre-University Science and Commerce College,Dharwad,India;3.Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research,KLE University,Belagavi,India;4.Department of Pharmacognosy, College of Pharmacy, KLE Academy of Higher Education and Research,KLE University,Belagavi,India;5.Brunel University London,Uxbridge,UK |
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| Abstract: | Mononuclear Co(III), Ni(II) and Cu(II) coordination compounds of (E)-1-(3,5-di-tert-butyl-2-hydroxybenzylidene)-2-(phthalazin-1-yl)hydrazine (LH) were prepared and characterized by physicochemical and spectroscopic methods. The metal-to-ligand ratio was found to be 1:2 in Co(L)2]Cl·2H2O (1) and Ni(L)2]·2H2O (2), while it is 1:1 in Cu(L)Cl]·2CH3OH (3). The X-ray crystal structures of LH and complex 1 is are reported. LH shows monobasic behavior, coordinating through NNO donor atoms. The complexes were investigated for their antimicrobial properties. Complexes 1 and 3 show excellent antibacterial and antifungal activities, respectively. |
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