Synthesis, characterization and antibacterial activity of azomethine derivatives derived from 2-formylphenoxyacetic acid |
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Authors: | Iqbal Amjid Siddiqui Hamid Latif Ashraf C M Ahmad Matloob Weaver George W |
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Affiliation: | Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan. itsamjid78@yahoo.com |
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Abstract: | A series of eight new azomethine derivatives were synthesized by reacting 2-formylphenoxyacetic acid with aromatic amines. The chemical structures of these compounds were confirmed by means of 1H-NMR, 13C-NMR, MS and elemental analysis. The compounds were assayed by the disc diffusion method for antibacterial against Staphylococcus aureus and Escherichia coli. Among the compounds tested, 2a, 2b, 2e, 2g and 2h exhibited good antibacterial activity, almost equal to that of Ciprofloxacin used as standard. |
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